• br Prognosis The management of AML in the

  2019-04-26

  

  Prognosis The management of AML in the elderly patient presents a significant challenge for hematologists. Careful evaluation of both patient and disease is required in each individual case to make optimal management decisions, and maximize the benefit to the patient. Apart from the extremely old

• br Conclusions br Acknowledgments We thank

  2019-04-26

  

  Conclusions Acknowledgments We thank webshop.elsevier.com for the assistance of the language-editing service. Introduction Sleep drives metabolite clearance from the adult histone methyltransferase (Xie et al., 2013) and promotes learning-dependent synapse formation and maintenance of sel

• Some patients developed osmotic demyelination disease ODS

  2019-04-26

  

  Some patients developed osmotic demyelination disease (ODS) after rapid correction of hyponatremia. Predisposing factors to development of ODS were syndrome of inappropriate antidiuretic hormone, alcoholism, liver cirrhosis, liver transplantation, renal failure, burns, malnutrition, or neoplasm. Oth

• br Hospitals in low income and middle

  2019-04-25

  

  Hospitals in low-income and middle-income countries receive surgical patients late, and usually when they are critically ill. Consequently, high perioperative mortality and poor surgical outcomes are the unacceptable results of the provision of surgical health care in these countries. However, the

• Despu s de haber propuesto a los

  2019-04-25

  

  Después de haber propuesto atipamezole los dioses como axis del modelo interpretativo, Pané abandona esta ineficaz grilla conceptual y nos proporciona una “desordenada” descripción de la religión indígena (desordenada, por supuesto, desde el punto de vista cristiano, ya que en el orden narrativo el

• br Discussion Our results confirm that germline variations i

  2019-04-25

  

  Discussion Our results confirm that germline variations in the TPMT gene are associated with treatment outcome in children with ALL [5]. The ability of TPMT to catalyze S-methylation and inactivate 6-mercaptopurine makes it a major determinant of 6-mercaptopurine toxicity. Furthermore, reduced TP

• After the success of the Millennium Development Goals

  2019-04-25

  

  After the success of the Millennium Development Goals and the reduction in more than 50% of child mortality in children younger than 5 years (Countdown to 2015 report), the survive and thrive motto was given prominence by the Sustainable Development Goals (SDGs). For all children to thrive, we need

• br In the past year

  2019-04-25

  

  In the past year, migration to Europe from Africa and the Middle East has reached unprecedented levels. In 2016, 181 405 migrants reached the shores of Italy and more than 5000 died trying to reach the southern coasts of Europe. Many migrants seek to escape war, poverty, persecution, or ill treatm

• The reduction in mother to child transmission MTCT of HIV

  2019-04-25

  

  The reduction in mother-to-child transmission (MTCT) of HIV is one of the greatest success stories of the antiretroviral therapy (ART) era. However, evidence is accumulating that, despite avoiding HIV, HIV-exposed uninfected (HEU) infants have more infectious morbidity and mortality than HIV-unexpos

• br Discussion Catheter ablation has played an increasingly i

  2019-04-25

  

  Discussion Catheter ablation has played an increasingly important role in controlling VT episodes in patients with structural BMN673 disease who have an ICD [6–10]. LPs recorded at an endocardial ventricular site reflect slow conduction into a protected zone. Strategies for the successful ablati

• tropisetron br Radiofrequency ablation Application of single

  2019-04-25

  

  Radiofrequency ablation Application of single radiofrequency tropisetron to the earliest atrial activation site during tachycardia terminated the tachycardia and restored sinus rhythm (Fig. 4). Because the local AF in the SVC continued, we confirmed that isolation of the SVC from the RA had been

• br Discussion Clinically HES may be separated into

  2019-04-25

  

  Discussion Clinically, HES may be separated into two subgroups: HES with, and HES without gene abnormality such as PDGFRA, PDGFRB, or FGFR1. The standard therapy of HES without gene abnormality is steroid; by contrast, the first-line therapy of HES with gene abnormality is imatinib. Although in-

• The management of PEComa follows the same treatment principl

  2019-04-25

  

  The management of PEComa follows the same treatment principles as other subtypes of soft tissue sarcoma. Surgical resection remains the primary treatment modality. There is no consensus on the administration of adjuvant treatment. Other treatment options, including chemotherapy and radiotherapy, hav

• Introduction Verapamil sensitive idiopathic left ventricular

  2019-04-25

  

  Introduction Verapamil-sensitive idiopathic left ventricular tachycardia (ILVT) has been shown to be a clinical entity of left-sided idiopathic ventricular tachycardia (VT) [1,2]. In electrophysiological studies, two specific local potentials, the diastolic Purkinje (Pd) potential and presystolic P

• In this issue of Mark Nicol and

  2019-04-25

  

  In this issue of , Mark Nicol and colleagues report the diagnostic accuracy of two commercially available rapid urine tests to identify active tuberculosis in children. Lipoarabinomannan is a unique component of the mycobacterial abscisic acid that is excreted in the urine of some patients with tube

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