• br Conclusion br Author Contributions br Competing Financial

  2018-10-23

  

  Conclusion Author Contributions Competing Financial Interests Acknowledgement This study was supported by Research Grant Council General Research Fund (HKU-17613815) to Tatia M.C. Lee. The funding agency has no roles in study design, data collection, data analysis, finding interpretation

• br Methods br Discussion We systematically searched the

  2018-10-23

  

  Methods Discussion We systematically searched the literature from the last five years to identify potential blood biomarkers for cancer (Hanahan & Weinberg, 2011; Cree, 2011). The data mining process retrieved 3990 citations from the initial 19, 724 records, screening the abstracts of these ci

• It could be argued that

  2018-10-23

  

  It could be argued that the lack of association between pre-diagnostic Treg/tTL ratios and CVD risk in the present study is due to the fact that plaques represent a different immunological compartment than blood (Grivel et al., 2011), and it remains to be determined whether Treg levels in blood adeq

• Strikingly even though glucose uptake

  2018-10-23

  

  Strikingly, even though glucose uptake is not affected by the local collagen microenvironment in 4T1 or 4T07 cells, the fate of the glucose-derived carbon is regulated by collagen density. In HD collagen, the oxidation of glucose for the TCA cycle is greatly diminished in both cell lines. There are

• br Materials and Methods br Results br Conclusion Our

  2018-10-23

  

  Materials and Methods Results Conclusion Our meta-analysis suggested that DNMT1 rs16999593 and DNMT3A rs1550117 could contribute to GC and that DNMT3B rs1569686 might function as a protective factor against gastric carcinogenesis. By using these significant SNPs as biomarkers, it is feasibl

• MITF has previously been described

  2018-10-23

  

  MITF has previously been described as having both oncogenic and tumour suppressor properties within melanoma (Hartman and Czyz, 2015; Levy et al., 2006). This idea is further perpetuated by the fact that while BRN2 and MITF have been shown to be expressed in two mutually exclusive populations, BRN2

• In summary we demonstrated that SMAD rs CT TT

  2018-10-23

  

  In summary, we demonstrated that SMAD4 rs12455792 CT, TT genotypes might increase the risk of TAAD by promoting proteoglycans degradation and SMCs apoptosis. To the best of our knowledge, this is the first study of relationship between functional polymorphisms of SMAD4 and pathogenic mechanism of TA

• br Funding This work was funded by the National Institutes

  2018-10-23

  

  Funding This work was funded by the National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID) contract HHSN272200800047C to EP. The Kawempe Community Health Study was funded entirely by the Tuberculosis Research Unit (grant N01-AI95383 and HHSN266200700022C

• br Stress Accelerates Telomere Shortening Although

  2018-10-23

  

  Stress Accelerates Telomere Shortening Although cellular replication is a major contributor to telomere attrition, other factors can affect the rate at which telomeres shorten. For example, it has been extensively reported that telomere shortening is accelerated when ubiquitin activating enzyme a

• inhibitor of apoptosis Our data indicated that CRP may be as

  2018-10-23

  

  Our data indicated that CRP may be associated with tissue lesions. In addition to hepatic synthesis (Pfafflin and Schleicher, 2009), CRP can be synthesized by lung inhibitor of apoptosis (e.g. epithelial cells, lymphocytes) (Ramage et al., 2004; Marc et al., 2004). However, local production in extr

• br Analysis of binding interface Direct atom

  2018-10-23

  

  2. Analysis of binding interface Direct fructose 1 6 bisphosphatase to atom contacts between BCMA and the VH and VL of J22.9-xi were identified using the PISA interaction server [9]. Direct and indirect hydrogen bonding interactions involving water were identified and validated (distance and geom

• The failure wave which is one of the most

  2018-10-22

  

  The failure wave, which is one of the most important discoveries in impact dynamics field over the last 20 years, is a new brittle failure mechanism of some brittle materials, such as glass and ceramics, etc., under compressive shock loading. It was observed by Rasorenov [7] and Kanel [8] through an

• Trabajos como el de Chandra Talpade Mohanty van en

  2018-10-22

  

  Trabajos como el de Chandra Talpade Mohanty (2008) van en esta misma dirección cuando muestran que, desde las posiciones marginales, se pueden interrogar las identidades hegemónicas. Para ella, se puede leer la escala ascendente del privilegio, acceder y hacer visibles los mecanismos del poder GSK46

• In our study we first obtained a panel

  2018-10-22

  

  In our study, we first obtained a panel of anti-pre-S antibodies, including one antibody highly specific for pre-S1 domain, and one specific for pre-S2 domain. We also harvested an antibody that could efficiently recognize the LHBs, and evaluated it’s clinical application. Of our recruited 537 patie

• Introduction Urbanization is an important social process

  2018-10-22

  

  Introduction Urbanization is an important social process of human society in the 21st Century. People keep flowing into cities, making cities grow on a continuous basis. When people stop moving to cities, urbanization will also stop accordingly. Typical definitions on urbanization include: (1) Urba

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