• It was while discussing Ricardo s machinery question that

  2018-11-09

  

  It was while discussing Ricardo\'s machinery question that Wicksell (1934 [1901,1911], p. 137) first maintained that a diminution in aggregate output as a result of technical progress was inconceivable under free competition, where there are no unexploited gains from trade. This “appears to be self-

• Statin therapy and more recently PCSK monoclonal

  2018-11-09

  

  Statin therapy and more recently PCSK9 monoclonal hdac inhibitor have demonstrated robust efficacy for lowering LDL-c but there remains significant unmet medical need especially for patients that are refractory or intolerant to these treatment. A recent study, found that of 647 patients with corona

• Previous studies have implicated impaired autophagy in Col a

  2018-11-09

  

  Previous studies have implicated impaired autophagy in Col6a1−/− muscles, which lead to the inability to degrade degenerated mitochondria, causing permeability transition pore opening and eventually resulting to apoptotic cell death (Grumati et al., 2010; Irwin et al., 2003). In the muscles of our C

• Phytochemicals including polyphenols and saponins

  2018-11-08

  

  Phytochemicals including polyphenols and saponins are prominent for their diverse health benefits including antioxidant and antidiabetic activities [44]. In this study, polyphenolics (total phenolics, tannins and total flavonoids) and total saponins were quantified in B. eurycoma and D. microcarpum

• The influence of the timing and

  2018-11-08

  

  The influence of the timing and orientation of the cleavage plane on early cell fate predetermination at the two-cell stage has been supported by molecular experiments on the expression profile of key transcriptional factors such as CDX2 (Jedrusik et al., 2008), the kinetics of OCT4 (Plachta et al.,

• bcr-abl inhibitor Regarding JNK phosphorylation levels were

  2018-11-08

  

  Regarding JNK, phosphorylation levels were either moderately (for JNK 1) or significantly increased (for JNK 2/3) at 5μM SB203580 compared to DMSO controls; these effects were further pronounced at 30μM (Figs. 5 A–B, schema in Figs. 6 C–D). This suggests a concentration-dependent activation of JNK b

• Several published studies on this topic provide insights int

  2018-11-08

  

  Several published studies on this topic provide insights into the relationship between the two cell types but there is still a limited knowledge concerning the proliferation behavior of cells in coculture. For a detailed analysis on cell proliferation in coculture, immunomagnetic beads coupled with

• Electric fields EFs provide a powerful signal

  2018-11-08

  

  Electric fields (EFs) provide a powerful signal with which to stimulate and guide migration of many types of cells in vitro, including NSCs (Cao et al., 2013; Feng et al., 2012a; Li et al., 2008; Meng et al., 2011; Yao et al., 2008, 2009; Zhao et al., 2006). Normally, weak EFs in the neuraminidase i

• protoporphyrin ix The following is the supplementary data re

  2018-11-08

  

  The following is the supplementary data related to this article. Acknowledgments This work was partially supported by a grant (NSC98-2311-B-003-MY3 and NSC101-2311-B-003-005) to Y. Lin from the National Science Council, Taiwan. We are grateful for the help from the Molecular Imaging Core Facilit

• Progression of maladaptive LV remodeling increased wall stre

  2018-11-08

  

  Progression of maladaptive LV remodeling, increased wall stress and transition to heart failure are associated with an enhanced cardiac production of natriuretic peptides (Hohl et al. 2013; van Veldhuisen et al. 2013). TAC led to a marked five- to twenty-fold increase of myocardial BNP and ANP expre

• br Results br Discussion The clinical success of haematopoie

  2018-11-08

  

  Results Discussion The clinical success of haematopoietic stem/progenitor cell (HSPC) therapy for large bowel disorders is poor, partly due to their limited recruitment following systemic administration. However, cellular therapy may be made effective if systemically transplanted beta lactamas

• br Resource table br Resource details An induced

  2018-11-08

  

  Resource table Resource details An induced pluripotent stem cell (iPSC) line had been generated from human skin fibroblasts of a male, symptomatic 33-year-old spinocerebellar type 2 (SCA2) patient (anonymized as H271) using episomal vectors carrying transcripts for human OCT4, SOX2, KLF4, L-MY

• Embryonic stem cells ESCs display two important characterist

  2018-11-08

  

  Embryonic stem pka kinase (ESCs) display two important characteristics: self-renewal, which allows them to be indefinitely expanded while maintaining the undifferentiated state, and pluripotency, which allows them to differentiate into almost all cell types. ESCs are able to differentiate into all

• Discussion A genome scale location analysis using published

  2018-11-08

  

  Discussion A genome-scale location analysis using published data (Gifford et al., 2013) was performed to identify surface proteins that have promoters occupied by POU5F1(OCT4)/SOX2/NANOG (OSN). In total, 30 (6%) of the 496 proteins identified on the surface of hPSCs have promoters occupied by OSN (

• In conclusion we expect that this

  2018-11-08

  

  In conclusion, we expect that this VP64dCas9-BFPVP64 platform, which is significantly more potent than previous versions, will encourage the adoption of CRISRP/Cas9-based TF technology to achieve multiplexed gene activation for reprogramming as well as nonreprogramming applications in basic science,

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