• br Materials and methods br Data analysis All results are

  2018-11-06

  

  Materials and methods Data analysis All results are presented as means±SEM. Comparisons between groups were analyzed using t-tests (two-sided). Differences with p values of less than 0.05 were considered significant. The p values were corrected for multiple testing procedures and to control ty

• We derived ESC lines from blastocysts of the double transgen

  2018-11-06

  

  We derived ESC lines from blastocysts of the double transgenic mouse line Mlc2v-Cre; Rosa26-Yfp, in which Cre and Yfp are specifically knocked into the Mlc2v and Rosa26 gene loci, respectively. Mlc2v-Cre-mediated removal of a stop sequence in the Rosa26-YFP reporter line results in expression of YFP

• To investigate apoptosis onset in hESC propagation we explor

  2018-11-06

  

  To investigate apoptosis onset in hESC propagation, we explored the possibility of apoptosis attenuation and its effect on hESCs survival. In the established H1-Bcl-xL hESCs, an anti-apoptotic gene, Bcl-xL, is ectopically expressed by an inducible expression system. Our studies demonstrated that H1-

• The second most stable reference gene in the present study

  2018-11-06

  

  The second most stable reference gene in the present study comparing OA- and healthy BMSCs is IPO8. The IPO8 gene product is a member of the importin-β family responsible for the nuclear import of proteins (Dean et al., 2001). Furthermore, it is involved in cytoplasmic miRNA-guided gene silencing an

• In our study ERK and JNK inhibitors

  2018-11-06

  

  In our study, ERK and JNK inhibitors effectively inhibited the migration of glioma glucose assay while the effect of the p38 inhibitor was not as significant. Hence, we further evaluated the effect of downregulation of uPAR and cathepsin B on the expression of ERK and JNK. Reduction in the expressi

• In contrast to the variable descriptions of heart regenerati

  2018-11-06

  

  In ret proto oncogene to the variable descriptions of heart regeneration in amphibians, zebrafish can regenerate following multiple types of cardiac injury including ventricular resection, cryoinjury and genetic cardiomyocyte ablation (Gonzalez-Rosa et al., 2011; Poss et al., 2002; Wang et al., 2011

• buy BMS-754807 In demyelinating diseases injury of myelin ol

  2018-11-06

  

  In demyelinating diseases, injury of myelin/oligodendrocytes results in a profound loss of myelin sheaths, axonal injury and degeneration, which eventually lead to long-lasting functional disabilities (Franklin and Ffrench-Constant, 2008; Emery, 2010). Mouse models of oligodendrocyte injury, such as

• NSC59984 br Materials and methods br Results and

  2018-11-06

  

  Materials and methods Results and discussion Acknowledgments Introduction Reprogramming rejuvenates aged somatic cells back into the pluripotent state (Takahashi et al., 2007; Takahashi and Yamanaka, 2006). The developmental plasticity of induced pluripotent stem cells (iPSC) demonstrate

• Our experiments suggest that Runx may be a

  2018-11-06

  

  Our experiments suggest that Runx1 may be a useful target to manipulate in order to direct the endogenous NSPC proliferative response toward maximal neurogenesis following traumatic Purmorphamine injury. Runx1 over-expression has been demonstrated to facilitate neuronal differentiation and long-rang

• br Results br Discussion In this study we examined

  2018-11-06

  

  Results Discussion In this study, we examined the behavior of NPCs in response to CsA using both in vitro and in vivo models. The in vitro and in vivo studies show that CsA effectively increases the size of the NPC population. Given that SVZ-derived neurospheres are comprised of approximately

• br Resource table br Resource details Peripheral blood monon

  2018-11-06

  

  Resource table Resource details Peripheral blood mononuclear cells (PBMC) were separated from whole blood and transduced by reprogramming vectors carrying four Yamanaka factors, Oct4, Sox2, Klf4, and c-Myc included in the CytoTune-iPS 2.0 Sendai Reprogramming Kit (Invitrogen). The four Yamanak

• br Results br Discussion The

  2018-11-06

  

  Results Discussion The selfish spermatogonia selection hypothesis proposes that pathogenic everolimus cost in human PAE disorders become enriched through clonal expansion of mutant SSCs that possess an acquired competitive advantage (Goriely and Wilkie, 2012). Here, we modeled stem cell fitne

• Although previous studies have demonstrated the

  2018-11-05

  

  Although previous studies have demonstrated the ability of research-grade HuCNS-SC lines to differentiate in both immune-suppressed and immune-deficient models (Cummings et al., 2005; Sontag et al., 2014; Ager et al., 2015), we observed no terminal differentiation in the current study. In our prior

• In this work we sought to commandeer

  2018-11-05

  

  In this work, we sought to commandeer an endogenous gene promoter to engineer custom-designed stem cells with the ability to regulate anti-cytokine therapy in an autonomous, real-time fashion. Critical to our selection of Ccl2 as the target locus for controlling transgene expression is the temporal

• The nanofilm refractive index n and the thickness d

  2018-11-05

  

  The nanofilm refractive index n and the thickness d (in nm) were measured with the use of a spectral ellipsometer HORIBA Jobin Yvon. Integral light transmission T (in %) of nanocomposite samples in the visible spectral range of 400–800 nm was recorded with a microspectrometer FSD-8 and processed wit

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