• Of the many different types

  2023-01-29

  

  Of the many different types of DNA lesions, DNA double strand breaks (DSBs) are amongst the most deleterious. It has been suggested that a single unrepaired DSB may be sufficient to induce cell death (Bennett et al., 1993), whereas misrepaired DSBs can result in loss of genetic information, potentia

• Therefore a number of homoisoflavonoids may be designed in f

  2023-01-29

  

  Therefore, a number of homoisoflavonoids may be designed in future that may be effective against angiogenesis for treating ocular neovascularization. As this cathepsin g current study deals with robust molecular modeling techniques on SH-11037 (cpd 15) and related homoisoflavonoids and SH-11037 has

• AR Vs are truncated AR proteins lacking the AR ligand

  2023-01-29

  

  AR-Vs are truncated AR proteins lacking the AR ligand-binding domain (AR-LBD) [6]. While AR-Vs have frequently been detected in CRPC, their expression and functional role in benign prostate tissues and primary prostate cancers is not readily apparent. Structural rearrangements in the AR gene and alt

• br Experimental procedures br Results br Discussion

  2023-01-28

  

  Experimental procedures Results Discussion Acknowledgments SRE and EBL contributed equally to this glibenclamide work. SRE, EBL, and MJT designed experiments, SRE, EBL, MCH, and AEI conducted experiments, SRE and EBL analyzed data, and EBL and MJT wrote the manuscript. We would like to

• L-Cysteinesulfinic acid synthesis The present study determin

  2023-01-28

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that L-Cysteinesulfinic acid synthesis non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atheroscl

• br Liver specific AHR deficiency and

  2023-01-28

  

  Liver-specific AHR deficiency and energy balance In contrast to the amelioration of hepatic steatosis by global AHR deficiency, targeted knockout of Ahr in hepatocytes exacerbated it in B6 mice fed on a high-fat diet, without interfering with body weight gain [21]. This appeared to result from au

• Mechanistically NAergic signaling in the

  2023-01-28

  

  Mechanistically, NAergic signaling in the VTA modulates neuronal activity presumably via α1-AR. The majority of α1-ARs are found in the VTA are located presynaptically on unmyelinated NPPB and axon terminals of glutamatergic and GABAergic neurons. However, α1-ARs are also found on neuronal dendrite

• br Detection and possible treatments for prostate cancer PC

  2023-01-28

  

  Detection and possible treatments for prostate cancer PC can be diagnosed, by screening for prostate-specific antigen (PSA) and after diagnosis, treatments may include intense observation, radical prostatectomy, radiation, chemotherapy, hormone therapy or vaccination depending on the type and sta

• In recent years there have been further significant developm

  2023-01-28

  

  In recent years, there have been further significant developments that enhance an understanding of the role of adenosine in nociception. Thus, novel methods of recruiting adenosine A1Rs have been developed, and the role of adenosine A2A- and A3Rs in nociception has been further elaborated. Furthermo

• The specific binding domain between PGK

  2023-01-28

  

  The specific binding domain between PGK in group B strepotocci (GBS) and actin had been reported . PGK as the actin-binding protein identified in TMW 1.1434, which displayed highly significant adhesion was investigated for the binding sites and compared to bacteria with less strong adhesion to actin

• Z-DQMD-FMK Further evidence for ACh GABA cotransmission had

  2023-01-28

  

  Further evidence for ACh/GABA cotransmission had also been observed in the cortex. Extensive axonal arborization from cholinergic BF neurons exists throughout the cortical layers, allowing direct observation of cholinergic synaptic terminals. One study in the visual cortex of cat examined immunolabe

• However there are studies revealing the dark side of autopha

  2023-01-28

  

  However, there are studies revealing the “dark side” of autophagy at later stages in cancers, when oncogenes (mainly K-ras and B-raf) are activated and/or tumour suppressors such as PTEN and p53 are inactivated. These studies are based on the use of GEMM and deletions of essential autophagy genes (A

• br Breast cancer The interactions between LOX

  2023-01-28

  

  Breast cancer The interactions between 15-LOX and COX enzymes also affect the outcome of breast cancer. Indomethacin, a COX-1 and COX-2 inhibitor, decreased the growth of human breast cancer (BC) cells in nude mice, as well as slowed the rate of lung metastasis formation [41]. The levels of 12-HE

• br Materials and methods br Results

  2023-01-28

  

  Materials and methods Results Discussion Fluoride can readily penetrate cellular membranes and seriously damage the structure and physiological function of cells (Zhou et al., 2015). Several studies have shown that excessive fluoride can decrease the viability of cells and that the growth o

• In addition unconventional mechanisms of internalization can

  2023-01-28

  

  In addition, unconventional mechanisms of internalization cannot be ignored. It is generally believed that the conventional homologous internalization of a GPCR depends on the activation of G proteins, since GRK activation requires the pre-activation of G proteins (Fig. 2). Feng et al. demonstrated

15077 records 304/1006 page Previous Next First page 上5页 301302303304305 下5页 Last page