• Pediatric cancers are fundamentally different from

  2022-05-06

  

  Pediatric cancers are fundamentally different from adult tumors and usually display a lower mutational burden and a faster growth rate. About 30% of all childhood malignancies are solid tumors and, in a majority of cases, respond well to chemotherapy. However, in particular in neuroblastoma the succ

• At the second step blind

  2022-05-05

  

  At the second step, blind docking simulation of 150 independent runs was performed with smaller grid box. Structures of open (1v4t.pdb), semi-closed (4dch.pdb) and two structures of closed configuration of GK (pdb codes are 1v4s and 3vev) were used for simulation (for detailed explanations on can se

• Rare mutations can impair the

  2022-05-05

  

  Rare mutations can impair the molecular function of GR and alter tissue sensitivity to GCs in humans, resulting in primary generalized GC resistance (PGGR) and hypersensitivity (PGGH) [14]. Familial and sporadic PGGR, or Chrousos Syndrome, is characterized by general and partial insensitivity of tis

• br Presenilins in protein trafficking proteolysis and degrad

  2022-05-05

  

  Presenilins in protein trafficking, proteolysis and degradation An obvious explanation for the role of presenilins and γ-secretase in protein trafficking and degradation is that many reported γ-secretase substrates are functionally involved in protein transport. For example, members of the mammal

• Subsequently BAs are secreted in the portal vein by the

  2022-05-05

  

  Subsequently, BAs are secreted in the portal vein by the heterodimeric organic solute transporter OSTα/β [15]. At this level, BAs are transported back to the liver, where the great majority is reabsorbed by the sodium (Na)-Taurocholate Cotransporter Protein (NTCP) and organic anion transporting poly

• To understand the impact of alterations in brain zinc homeos

  2022-05-05

  

  To understand the impact of alterations in reverse transcriptase inhibitors zinc homeostasis, the role of Zn2+ as a neurotransmitter has to be appreciated. Certain regions of the brain including the neocortex and hippocampus harbour so-called “zincergic” (or “gluzinergic”) neurons, where Zn2+ is co-

• ADAM has two alternative splicing

  2022-05-05

  

  ADAM12 has two alternative splicing forms, a membrane-anchored long form (ADAM12-L) and a secreted short form (ADAM12-S). Both the long and short forms have metalloproteinase, disintegrin, cysteine-rich, and epidermal growth factor-like domains and can shed pro-heparin binding-epidermal growth facto

• Although drug monitoring is not

  2022-05-05

  

  Although drug monitoring is not usually requested, there are some cases where measurement of DOACs in Estradiol valerate synthesis is useful, and of special help for managing patients at risk. These cases include the control of adherence to a therapeutic protocol, surveillance of drug accumulation

• Here we employ a genetic

  2022-05-05

  

  Here we employ a genetic approach to examine the potential interaction of Gli3 and Ezh2 with respect to anteroposterior limb bud polarity. Loss of Ezh2 in a Gli3 mutant background leads to synergistic loss of anterior identity, although the double mutant phenotype more closely resembles that of Ezh2

• br Significance Cellular heterogeneity for phenotypic

  2022-05-05

  

  Significance Cellular heterogeneity for phenotypic features is a key mechanism underlying disease progression and therapeutic resistance, yet its regulation is poorly understood at the molecular level. Our findings demonstrate that endocrine resistance is associated with higher transcriptomic het

• We reveal that the four well

  2022-05-05

  

  We reveal that the four well known vertebrate families of KAT enzymes (GNAT, MYST, P300/CBP, Basal transcription factor/nuclear receptor co-activator) seem to be conserved (Karmodiya et al., 2014; Roth et al., 2001; Sheikh & Akhtar, 2018) in the mangrove rivulus, together with Camello, a potential n

• PFI-2 br Results br Discussion Our

  2022-05-05

  

  Results Discussion Our current study demonstrates that the sustained activation of Yap overrides the p27-mediated checkpoint, at least in part, through the degradation of FoxO family proteins, allowing polyploid cells to proliferate inappropriately with mitotic defects and resulting in centros

• br Concluding remarks br Conflict of interest statement

  2022-05-04

  

  Concluding remarks Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We thank all the present and former members in our laboratory for their contributions to

• As a result of the capability of modulating the

  2022-05-04

  

  As a result of the capability of modulating the dynamic changes and rearrangement of cytoskeletons, the Rho GTPases, in which RhoA, Cdc42 and Rac1 are best-characterized, have been highlighted as significant contributors for orchestrating neuronal development (Duman et al., 2015, Heasman and Ridley,

• Two genes PATL and RASSF whose relationship to HIV

  2022-05-04

  

  Two genes (PATL2 and RASSF1), whose relationship to HIV infection had not previously been reported, were identified in this study. Although PATL2 and RASSF1 have been implicated in cell division and tumor suppression, respectively (Scheller et al., 2007, Rather et al., 2014, Liu et al., 2002), their

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