• br Case report A year old

  2019-06-14

  

  Case report A 50-year-old man with no known systemic diseases presented to our facility with a growing huge mass at his left flank and numbness of the left leg. Five years earlier, there was only a small lump over his left flank. However, the soft tissue lesion gradually enlarged, accompanied by

• br Clinical characteristics Brugada syndrome is more common

  2019-06-14

  

  Clinical characteristics Brugada syndrome is more common in Southeast Asia, including Japan, with an estimated prevalence of 12 in 10,000 individuals, compared with Western countries where the estimated prevalence is 1 to 5 in 10,000 individuals. However, the incidence of early repolarization syn

• Tobacco use is poised to kill as many as

  2019-06-14

  

  Tobacco use is poised to kill as many as 1 billion people in the 21st century, primarily from non-communicable diseases. Less often noted is the effect of tobacco use and second-hand smoke exposure on maternal and child health. Cigarette smoking during pregnancy poses serious risk to the mother and

• Lo and colleagues also add to the

  2019-06-14

  

  Lo and colleagues also add to the evidence that MDA might need to be widened beyond school-aged children (5–14 years). Different frequencies of treatment are known to be needed for communities with different intensities of infection, but less appreciated is that different age groups need to be treat

• The deletion of q seen

  2019-06-14

  

  The deletion of 14q seen in our patient included the IGH locus at 14q32.33. This is noteworthy, because loss of 14q has been reported as a recurrent aberration acquired during the natural history of CLL. The acquisition of a del(14) may thus be indicative of CLL in transformation. In a study of a la

• The PAX gene encodes a transcriptional factor which is

  2019-06-14

  

  The PAX5 gene encodes a transcriptional factor, which is specifically expressed at the early stages of B-cell differentiation and it is required for B-cell development. Its dysregulation is involved in the leukemogenesis of B-ALL. The PAX5 gene rearrangements account for approximately 2.5% of pediat

• Mifepristone Besides MPO the infiltrated neutrophils in IR i

  2019-06-13

  

  Besides MPO, the infiltrated neutrophils in IR injured liver can produce INFγ to enhance TLR4 signaling, stimulate KCs activation, and induce Th1 inflammation responses. Subsequently, M1/Th1 Mifepristone produce INFγ to enhance neutrophil infiltration in the process of hepatic and renal IR injury.

• Patients with heart failure are at

  2019-06-13

  

  Patients with heart failure are at a high risk of mortality and morbidity. Medical expenses associated with heart failure are increasing, and approaches aimed at early heart failure detection and reduction of the hospitalization rate are yet to be developed. Patients with CIEDs also develop heart fa

• The concept of metronomic chemotherapy began in

  2019-06-13

  

  The concept of metronomic chemotherapy began in the 1990s, when Kerbel showed chemotherapeutic agents may be able to target tumor vessel endothelial cells. In 2000, Browder et al demonstrated a more frequent, lower dose of cyclophosphamide, i.e. anti-angiogenic schedule, could induce response in tum

• br Vascular cells and the peribiliary vascular plexus The

  2019-06-13

  

  Vascular cells and the peribiliary vascular plexus The liver is a highly vascularized organ that receives dual blood supplies from the hepatic portal vein (HPV) and hepatic glucosamine sulfate (Fig. 1). The HPV delivers approximately 75% of the total blood supply that the liver receives and carr

• br Results and discussion br

  2019-06-13

  

  Results and discussion Authorship contributions Conflict of interest Acknowledgments This work is supported by grants from the United States National Institutes of Health/National Cancer Institute: R01 CA098472 and R01 CA170334. We thank Dr. Dan Zhang and Andy Awwad for technical assista

• br Specific concerns of each

  2019-06-12

  

  Specific concerns of each VT substrate Complications Potential complications associated with epicardial catheter ablation of VTs are very rare and the procedures are generally safe [4–6,11,13–16,17,25,33–35]. However, transthoracic epicardial access and ablation could result in uncommon compli

• The starting point is to address

  2019-06-12

  

  The starting point is to address the huge gap in surveillance capabilities identified in 2014 by the WHO\'s first global report on surveillance of antimicrobial resistance. To address this p38 pathway gap, WHO\'s action plan is being implemented in phases from early 2016 onwards, gathering informat

• br Discussion Furthermore most of the previously

  2019-06-12

  

  Discussion Furthermore most of the previously described cases with a solitary lesion affecting bone involved the craniofacial bones [2–7], and only a few cases affected the appendicular skeleton. Several affected extra-craniofacial sites have been sporadically reported, for example: femur [8], ti

• br Although safe effective evidence based interventions that

  2019-06-12

  

  Although safe, effective, evidence-based interventions that O4I1 cost are simple enough to be provided at primary-care level exist, provision of safe abortion remains restricted to physicians and often only to gynaecologists in many parts of the world. WHO\'s new guideline highlights that moving

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