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We have recently reported a regulatory effect of quercetin o
2024-05-08
We have recently reported a regulatory effect of quercetin on the AChE activity in the brainstem during the demyelination and remyelination process [17]. It has also been observed that there is a protective effect on lipid peroxidation and worsening of motor functions caused by loss of myelin in the
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br Materials and methods br Results br Discussion
2024-05-08
Materials and methods Results Discussion Proteomics analyses generate mountains of data, expression information for hundreds or thousands of proteins in a single experiment (Wojcik and Schächter, 2000). Recently proteomics and bioinformatics provide new understandings about the processes in
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Several genes related to metabolism post
2024-05-08
Several genes related to metabolism, post-transcriptional regulation, chromatin structure, and signaling pathways are required for the sexual development and virulence of G. zeae (Baldwin et al., 2010, Bluhm et al., 2007, Ding et al., 2009, Han et al., 2007, Hou et al., 2002, Jenczmionka et al., 200
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In recent years the higher lipophilicity thus
2024-05-07
In recent years, the ‘higher lipophilicity’-thus-‘better performance’ tenet, derived from the polar paradox theory applied to micro-structured media, was challenged by novel and unexpected experimental results. In particular, the synthesis of many complete series of fatty palovarotene esters of nat
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Available data thus indicate that there are
2024-05-07
Available data thus indicate that there are at least two ways that HMGA proteins can induce localized changes in the chromatin structure of inducible gene promoters, both of which involve positioned nucleosomes that must be “remodeled” before gene transcription can occur. The first mechanism is exem
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br Experimental section br Acknowledgements
2024-05-07
Experimental section Acknowledgements This work was funded by the Italian Association for Cancer Research (AIRC IG18590 to A.A.), by “Fondi di Ateneo-University of Pisa” years 2009 and 2010 (E. N., S. N., E. O., and A. R.) and partially by the Unipi project P.R.A.2016_27 (E. N., E.O. and A. R.
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Use of RASB is associated with potential concerns
2024-05-07
Use of RASB is associated with potential concerns about side effects such as acute kidney injury or hyperkalemia, and clinicians are reluctant to prescribe RASB in patients with severe renal dysfunction (estimated GFR guideline, our data showed that the effects of ARB were greater in patients witho
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Pentamidine dihydrochloride The advantage of active immunoth
2024-05-07
The advantage of active immunotherapy is long-term antibody production from short-term drug administration at limited cost. Conversely, immune response may be inconsistent or lacking, especially in older individuals, and adverse reactions—if immunologically based—may also be long-lasting. Initial ex
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br Funding This study was supported
2024-05-07
Funding This study was supported by a grant from the Science and Technology Program of Guangzhou (No. 2014Y2-00181) and the personnel training program of Southern Medical University (No. PY2015N023). Conflict of interest statement Authors’contributions Introduction Chronic cerebral hypo
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tivozanib mg Although AMPK is a negative regulator of bioene
2024-05-07
Although AMPK is a negative regulator of bioenergetic reprogramming in cancer cells, little is known about the role of AMPK in immunometabolism in sepsis. Our current study indicates that AMPKα dysfunction enhances PKM2-dependent aerobic glycolysis, which results in HMGB1 release in macrophages and
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The current study was designed
2024-05-07
The current study was designed to investigate the effects of the 12/15-LOX inhibitor, LOXBlock-1 (LB1) in mice using a FeCl3-induced distal MCAO model, and to test its utility in conjunction with subsequent thrombolysis with tPA, which is to date the only FDA-approved drug for acute stroke treatment
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br Materials and methods br Results br
2024-05-07
Materials and methods Results Discussion Knowledge of the molecular basis of an inherited genetic disease is crucial for understanding the disease pathology and, ultimately, for therapeutic design. Several recent reports have stressed the need for physical characterization of disease-associ
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Bamboo the fastest growing multipurpose woody plant with
2024-05-06
Bamboo, the fastest growing, multipurpose woody plant with a myriad of industrial and domestic uses is intricately associated with the cultural, social and economic conditions of people in many Asian countries. Its uses are not only limited to being used as a substitute for wood in construction, fur
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br Discussion Hepatic dysfunction in the
2024-05-06
Discussion Hepatic dysfunction in the metabolic syndrome is a driver of negative patient outcomes that requires more therapeutic options. The complexity of liver alterations in this disease – elevated de novo synthesis of fatty acids and cholesterol, reduced clearance of circulating atherogenic L
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br Preliminary remarks Expression of the
2024-05-06
Preliminary remarks Expression of the transcription factor aryl hydrocarbon receptor (AHR) and the AHR-repressor (AHRR) are both strikingly high in the Brassinolide mg of barrier organs skin and gut [1,2]. It is generally assumed that this reflects their role in linking environmental factors to a
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