• (S)-Mephenytoin in Translational Drug Metabolism: Beyond ...

  2025-09-27

  (S)-Mephenytoin, a gold-standard CYP2C19 substrate, is transforming translational research in oxidative drug metabolism and pharmacokinetics. This article uniquely explores its integration with hiPSC-derived intestinal organoids and addresses emerging challenges in modeling inter-individual variability, surpassing routine in vitro assays.

• Redefining CRISPR Precision: EZ Cap™ Cas9 mRNA (m1Ψ) in M...

  2025-09-26

  Explore how EZ Cap™ Cas9 mRNA (m1Ψ) elevates genome editing in mammalian cells through advanced mRNA engineering, Cap1 structure, and N1-Methylpseudo-UTP modification. This in-depth analysis highlights a new paradigm for specificity and safety in CRISPR-Cas9 genome editing.

• Y-27632 Dihydrochloride: Advanced ROCK Inhibition for Int...

  2025-09-25

  Explore the multifaceted role of Y-27632 dihydrochloride as a selective ROCK1/ROCK2 inhibitor in engineering the intestinal stem cell niche, with insights into cytoskeletal modulation, regenerative medicine, and the latest advances in ISC aging research. This article provides a unique, in-depth perspective on Rho/ROCK signaling pathway manipulation for next-generation stem cell and cancer studies.

• Unveiling HyperScribe™ T7: Transforming RNA Synthesis for...

  2025-09-24

  Discover how the HyperScribe T7 High Yield RNA Synthesis Kit advances in vitro transcription RNA kit technology for high-yield, functional RNA generation. This article uniquely explores its pivotal role in functional genomics and metastatic cancer research.

• Rucaparib (AG-014699): Illuminating PARP1 Inhibition and ...

  2025-09-23

  Explore the scientific advances of Rucaparib (AG-014699) as a potent PARP1 inhibitor in DNA damage response research, with a novel focus on its intersection with regulated cell death pathways. This article provides new insights for cancer biology research, particularly in PTEN-deficient and ETS gene fusion-expressing prostate cancer models.

• In this study we have isolated genes

  2025-04-19

  

  In this study, we have isolated Prestained Protein Marker (Triple color, EDTA free, 10-250 kDa) that encode ACL from G. zeae through random mutagenesis by restriction enzyme-mediated integration (REMI). The mutant Z39P186 where the ACL gene had been disrupted showed defects in vegetative growth, as

• While it is known that circulating LDL C

  2025-04-18

  

  While it is known that circulating LDL-C levels are largely regulated by either controlling the rate of hepatic production of its triglyceride-rich precursor VLDL particle or the rate of LDLR-mediated LDL particle clearance [58], it should be noted that important differences exist between rodents an

• Consistent with a damaging role for increased LOX activity

  2025-04-18

  

  Consistent with a damaging role for increased 12/15-LOX activity in stroke, systemic administration of the 12/15-LOX inhibitor, LB1, 2 h after permanent focal cerebral ischemia significantly reduced infarct size 24 h after the ischemia, and the treatment group demonstrated improved behavioral and he

• br Declaration of interest br Funding

  2025-04-15

  

  Declaration of interest Funding Introduction The endocrine disruptor bisphenol A (BPA) is a high-production chemical used in several consumer products, including polycarbonate bottles, epoxy resins, dental sealants, and thermal paper receipts (Geens et al., 2012). Importantly, BPA monomers

• Introduction Hepatocellular carcinoma HCC is one of

  2025-04-11

  

  Introduction Hepatocellular carcinoma (HCC) is one of the most difficult cancers to treat, and it threatens human health severely [1]. Although various interventions, including surgical operation, radiofrequency ablation, and chemotherapy, have been endorsed, the prognosis of HCC patients remains p

• br Metabolic effects of apelin in obesity and

  2025-04-11

  

  Metabolic effects of apelin in obesity and type 2 diabetes Mice fed a high fat diet (HFD) for several weeks become obese, hyperglycemic, hyperinsulinemic and insulin resistant. Acute apelin treatment by intravenous injection or by infusion during a hyperinsulinemic–euglycemic clamp in obese and i

• The functional similarity between GPR and APLNR ie both

  2025-04-10

  

  The functional similarity between GPR25 and APLNR, ie both can be activated by Apelin and Apela and are coupled to Gi-cAMP signaling pathway (Fig. 2, Fig. 3, Fig. 4), strongly suggests that GPR25 signaling may play important physiological and pathological roles in vertebrates more or less similar to

• Recently whey products have been added to nutritional bevera

  2025-04-09

  

  Recently, whey products have been added to nutritional beverages to boost their antioxidant capacity. Supplementation of a lemon drink with 1% WP hydrolyzed by subtilisin increased the antioxidant activity of the beverage from 0.75 to 7.79 mmol of TE/L (Athira et al., 2014). In addition, a flavored

• Formation of SAHFs in human cells

  2025-04-08

  

  Formation of SAHFs in human 3X (DYKDDDDK) Peptide is a dynamic and multifaceted process that is largely dependent on the p16/pRB ras-induced senescence pathway [108]. Many details remain to be elucidated but formation appears to be driven by a complex of histone chaperones (HIRA and ASF1a), a pRB/hB

• We have shown that an extensive region in

  2025-04-08

  

  We have shown that an extensive region in SERBP1 (amino acids 354 to 474, using co-ordinates based on the full-length isoform, Figs. 1a and 2) is necessary for it to interact with RACK1; since this region has substantial homology to the corresponding region of HABP1 (Fig. 3) it is a reasonable hypot

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